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Chemical Structure : CCG-4986
Catalog No.: PC-60210Not For Human Use, Lab Use Only.
A non-peptide, selective RGS4 inhibitor that inhibits RGS4/Gα(o) binding with 3 to 5 uM potency.
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A non-peptide, selective RGS4 inhibitor that inhibits RGS4/Gα(o) binding with 3 to 5 uM potency; shows selectivity for RGS4 and does not inhibit RGS8; binds to RGS4, inhibits RGS4 stimulation of Galpha(o) GTPase activity in vitro, and prevents RGS4 regulation of mu-opioid-inhibited adenylyl cyclase activity in permeabilized cells.
| M.Wt | 374.81 | |
| Formula | C13H11ClN2O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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2. Roman DL, et al. Mol Pharmacol. 2010 Sep;78(3):360-5.
3. Cheng YC, et al. Cell Mol Life Sci. 2013 Mar;70(5):935-50.
4. Chen Y, J Neurosci. 2012 Feb 22;32(8):2683-95.
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