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Chemical Structure : CCG-50014
CAS No.: 883050-24-6
Catalog No.: PC-70013Not For Human Use, Lab Use Only.
CCG-50014 (CCG50014) is a potent, selective, covalent inhibitor of RGS4 with IC50 of 30 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $68 | In stock | |
| 10 mg | $98 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | Get quote |
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CCG-50014 (CCG50014) is a potent, selective, covalent inhibitor of RGS4 with IC50 of 30 nM.
CCG-50014 dispalys >20-fold selective for RGS4 over other RGS proteins.
CCG-50014 binds in an allosteric regulatory site, does not inhibit activity of the cysteine protease papain.
CCG-50014 reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test.
CCG-50014 is a useful tool for studying the functional roles of RGS4.
| M.Wt | 316.35 | |
| Formula | C16H13FN2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-[(4-Fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione |
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1. Blazer LL, et al. Biochemistry. 2011 Apr 19;50(15):3181-92.
2. Vashisth H, et al. ACS Chem Biol. 2013 Dec 20;8(12):2778-84.
3. Yoon SY, et al. Anesth Analg. 2015 Mar;120(3):671-7.
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