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Chemical Structure : CCI-007
CAS No.: 939228-52-1
Catalog No.: PC-36025Not For Human Use, Lab Use Only.
CCI-007 (CCI 007) is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 100 mg | $698 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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CCI-007 (CCI 007) is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485.
CCI-007 induced a rapid caspase-dependent apoptosis with mitochondrial depolarization within 24h treatment.
CCI-007 altered the characteristic MLL-r gene expression signature in sensitive cells with downregulation of the expression of HOXA9, MEIS1, CMYC and BCL2, important drivers in MLL-r leukemia.
| M.Wt | 336.362 | |
| Formula | C15H16N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Ethyl-2-(4-((2-imino-4-oxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)acetate |
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1. Somers K, et al. Oncotarget. 2016 Jul 19;7(29):46067-46087.
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