Chemical Structure : CCKBR Gi-biased agonist 3qr
CAS No.:
2923120-30-1
CCKBR Gi-biased agonist 3qr
Catalog No.: PC-25772Not For Human Use, Lab Use Only.
CCKBR Gi-biased agonist 3qr is a potent, selective Gq-biased agonist of cholecystokinin (CCK) B receptor (CCKBR) with EC50 of 0.035 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CCKBR Gi-biased agonist 3qr is a potent, selective Gq-biased agonist of cholecystokinin (CCK) B receptor (CCKBR) with EC50 of 0.035 nM.
3r1 effectively increased the viability of primary cortical neurons in a concentration-dependent manner (EC50 = 0.037 nM), but not CCKBR Gi-biased agonist z-44.
3r1 (0.01 or 0.05 mg/kg) through intraperitoneal injection every day for 3 months significantly rescued neuronal apoptosis in 5×FAD mice, increases number of secondary branches and the axon length of neurons.
3r1 (0.01 or 0.05 mg/kg) significantly reduced the p-Tau (phosphorylated tau protein) level alleviated cognitive decline in AD mouse model.
3r1 reduces the number of plaques by increasing α-secretase activity and PLCB4 expression in 5×FAD mice.
Physicochemical Properties
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M.Wt
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699.60
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Formula
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C32H39BrN6O7
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-3-((S)-2-((S)-2-acetamido-3-(1H-indol-3-yl)propanamido)hexanamido)-4-(((S)-1-amino-3-(3-bromophenyl)-1-oxopropan-2-yl)amino)-4-oxobutanoic acid
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References
1. Wang JL, et al. Cell. 2025 Nov 20:S0092-8674(25)01238-3.
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