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Chemical Structure : CCR4-351
Catalog No.: PC-73031Not For Human Use, Lab Use Only.
CCR4-IN-38 (CCR4-351) is a potent, selective, orally bioavailable CCR4 antagonist with IC50 of 50 nM (Chemotaxis inhibition).
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CCR4-IN-38 (CCR4-351) is a potent, selective, orally bioavailable CCR4 antagonist with IC50 of 50 nM (Chemotaxis inhibition).
CCR4-IN-38 inhibits the recruitment of Treg into the tumor microenvironment (TME).
CCR4-IN-38 elicits antitumor responses as a single agent or in combination with an immune checkpoint blockade.
| M.Wt | 500.428 | |
| Formula | C24H27Cl2N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Omar Robles, et al. J Med Chem. 2020 Aug 13;63(15):8584-8607.
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