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Chemical Structure : CCR7 inhibitor Cmp1205
Catalog No.: PC-73250Not For Human Use, Lab Use Only.
CCR7 inhibitor Cmp1205 is an allosteric ligand and antagonist for human CC chemokine receptor 7 (CCR7) with Kd of 3 nM, suppresses arrestin binding in response to activation by CCL19 with IC50 of 7.3 uM.
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CCR7 inhibitor Cmp1205 is an allosteric ligand and antagonist for human CC chemokine receptor 7 (CCR7) with Kd of 3 nM, suppresses arrestin binding in response to activation by CCL19 with IC50 of 7.3 uM.
Cmp1205 binds to a pocket at the intracellular part of CCR7 between the ends of TM1, TM2, TM3, and TM6 and the loop between TM7 and H8.
Cmp1205 allosterically inhibits binding of the native chemokine CCL19 ligand in a membrane-based competition binding experiment with IC50 of 35 nM.
| M.Wt | 475.56 | |
| Formula | C22H29N5O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kathrin Jaeger, et al. Cell. 2019 Aug 22;178(5):1222-1230.e10.
2. Proj M, et al. Front Pharmacol. 2022 Mar 18;13:855653.
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