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Chemical Structure : CCT129202
CAS No.: 942947-93-5
Catalog No.: PC-42864Not For Human Use, Lab Use Only.
CCT129202 is a potent, selective, ATP-competitive pan-Aurora kinase inhibitor with IC50 of 42, 198 and 227 nM for Aurora A, Aurora B and Aurora C, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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CCT129202 is a potent, selective, ATP-competitive pan-Aurora kinase inhibitor with IC50 of 42, 198 and 227 nM for Aurora A, Aurora B and Aurora C, respectively.
CCT129202 displays high selectivity for the Aurora kinases over a broad range of 13 other kinases.
CCT129202 inhibits proliferation in multiple cultured human tumor cell lines (GI50=0.08-1.7 uM), induces aberrant mitosis that leads to apoptosis.
CCT129202 reduces phosphorylation of histone H3, stabilizes p53, and inhibits growth of HCT116 human colon cancer xenografts in athymic mice.
| M.Wt | 497.0156 | |
| Formula | C23H25ClN8OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Piperazineacetamide, 4-[6-chloro-2-[4-(dimethylamino)phenyl]-3H-imidazo[4,5-b]pyridin-7-yl]-N-2-thiazolyl- |
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1. Chan F, et al. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3147-57.
2. Cheng C, et al. Mol Pharm. 2012 Jul 2;9(7):1971-82.
3. Tobío A, et al. Antiinflamm Antiallergy Agents Med Chem.
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