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CCT241161

Chemical Structure : CCT241161

CAS No.: 1163719-91-2

CCT241161 (CCT 241161)

Catalog No.: PC-63267Not For Human Use, Lab Use Only.

CCT241161 is a potent pan-RAF inhibitor with IC50 of 30, 15 and 6 nM for BRAF, V600E-BRAF and C-RAF, also potently inhibits SRC and LCK (IC50=10 and 3 nM, respectively)..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CCT241161 is a potent pan-RAF inhibitor with IC50 of 30, 15 and 6 nM for BRAF, V600E-BRAF and C-RAF, also potently inhibits SRC and LCK (IC50=10 and 3 nM, respectively).

Physicochemical Properties

M.Wt 541.62
Formula C28H27N7O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-(methylthio)-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)urea

References

1. Girotti MR, et al. Cancer Cell. 2015 Jan 12;27(1):85-96.

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