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Chemical Structure : CCT271850
Catalog No.: PC-60230Not For Human Use, Lab Use Only.
CCT271850 is a potent, selective, orally bioavailable Mps1 kinase (TTK) inhibitor with IC50 of 11 nM.
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CCT271850 is a potent, selective, orally bioavailable Mps1 kinase (TTK) inhibitor with IC50 of 11 nM.
CCT271850 displays >1,000-fold selectivity over CDK-2, Aurora A/B and PLK1.
CCT271850 inhibits HCT116 cells growth with GI50 of 0.16 uM, sensitises selectively MSI+ colon cancer and basal breast cancer cell lines to cell death; active in vivo.
| M.Wt | 431.544 | |
| Formula | C24H29N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Faisal A, et al. Br J Cancer. 2017 Apr 25;116(9):1166-1176.
2. Innocenti P, et al. J Med Chem. 2016 Apr 28;59(8):3671-88.
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