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Chemical Structure : CCT374705
Catalog No.: PC-20503Not For Human Use, Lab Use Only.
CCT374705 is a potent, selective, in-vivo active BCL6 inhibitor with TR-FRET IC50 of 6 nM.
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CCT374705 is a potent, selective, in-vivo active BCL6 inhibitor with TR-FRET IC50 of 6 nM.
CCT374705 displays high selectivity for BCL-6 and minimal off-target interactions against a kinase panel (468).
CCT374705 exhibits antiproliferative activity BCL6-dependent cell line OCI-Ly1 and Karpas 422 with GI50 of 38.5 and 12.9 nM, respectively.
CCT374705 (50 mg/kg PO) demonstrates in vitro efficacyin a Karpas 422 xenograft model in mice, with a significant increase in ARID3A mRNA expression.
| M.Wt | 450.85 | |
| Formula | C21H18ClF3N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Alice C Harnden, et al. J Med Chem. 2023 Apr 7. doi: 10.1021/acs.jmedchem.3c00155.
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