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Chemical Structure : CCX-771
Catalog No.: PC-60212Not For Human Use, Lab Use Only.
CCX-771 is a potent, selective CXCR7 antagonist with IC50 of 4.1 nM.
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CCX-771 is a potent, selective CXCR7 antagonist with IC50 of 4.1 nM.
CCX-771 potently inhibits CXCL12-induced NC-37 cell transendothelial migration (TEM) with IC50 of 49 nM, 20 times greater than that of AMD3100 (IC50=830 nM).
CCX-771 also potently stimulates β-arrestin2 recruitment to CXCR7, with greater potency and efficacy than the endogenous chemokine ligands.
CCX-771 inhibits lesion formation and ameliorates hyperlipidemia after vascular injury and during atherosclerosis in Apoe(-/-) mice.
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10 mM in DMSO |
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