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Chemical Structure : CD33 splicing modulator 1
Catalog No.: PC-73327Not For Human Use, Lab Use Only.
CD33 splicing modulator 1 is a small-molecule CD33 pre-mRNA splicing modulator with EC50 of 7.8 uM, enhances the exclusion of CD33 exon 2, reduces full-length V-domain containing CD33 protein.
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CD33 splicing modulator 1 is a small-molecule CD33 pre-mRNA splicing modulator with EC50 of 7.8 uM, enhances the exclusion of CD33 exon 2, reduces full-length V-domain containing CD33 protein.
CD33/Siglec 3 is a myeloid lineage cell surface receptor that is known to regulate microglia activity.
CD33 splicing modulator 1 reduces full-length V-domain containing CD33 protein in meyloid lineage cells (EC50=2.1 uM), increases exon 2 skipping in cellular mRNA pools.
| M.Wt | 444.514 | |
| Formula | C25H25FN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Thomas A Chappie, et al. ACS Med Chem Lett. 2022 Jan 4;13(1):55-62.
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