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Chemical Structure : CDD-1281
Catalog No.: PC-49709Not For Human Use, Lab Use Only.
CDD-1281 (CDD1281) is a potent, selective inhibitor of BMP type 2 receptor BMPR2 with IC50 of 1.2 nM and Kiapp value of 8 nM.
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CDD-1281 (CDD1281) is a potent, selective inhibitor of BMP type 2 receptor BMPR2 with IC50 of 1.2 nM and Kiapp value of 8 nM.
CDD-1281 displays high selectivity (>110-fold–>830-fold) over other type 1 and type 2 TGFβ family kinases.
CDD-1281 inhibited BMP-mediated gene expression in mammalian cell cultures, suppressed BRE-reporter activity in a luciferase reporter (293T-BRE-Luc) assays with IC50 of 6.19 uM.
Pretreatment with CDD-1281 (25 uM) significantly decreased the phosphorylation of SMAD1/5 (pSMAD1/5) in BMP9 stimulation of pSMAD1/5 in HUVECs.
CDD-1281 is not only selective among the TGFβ family but also completely selective against >408 off-target kinases.
| M.Wt | 489.58 | |
| Formula | C30H27N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ram K Modukuri, et al. J Med Chem. 2023 Jan 31. doi: 10.1021/acs.jmedchem.2c01886.
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