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Chemical Structure : CDK12 inhibitor 2
Catalog No.: PC-35525Not For Human Use, Lab Use Only.
CDK12 inhibitor 2 is a potent, selective, non-covalent CDK12 inhibitor with IC50 of 52 nM, displays >192-fold selectivity over CDK2/7/8/9.
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CDK12 inhibitor 2 is a potent, selective, non-covalent CDK12 inhibitor with IC50 of 52 nM, displays >192-fold selectivity over CDK2/7/8/9; also potently inhibitor CDK13 with IC50 of 10 nM; inhibits the phosphorylation of Ser2 in the C-terminal domain (CTD) of RNA polymerase II in SK-BR-3 cells at low submicromolar concentrations (iC50=0.195 uM), inhibits the growth of SK-BR-3 cells with IC50 of 0.8 uM.
| M.Wt | 532.648 | |
| Formula | C32H32N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ito M, et al. J Med Chem. 2018 Aug 1. doi: 10.1021/acs.jmedchem.8b00683.
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