Chemical Structure : CDRI-1709S
CAS No.:
CDRI-1709S
Catalog No.: PC-27859Not For Human Use, Lab Use Only.
CDRI-1709S is a highly potent, selective small molecule AdipoR1 (Adiponectin receptor 1) agonist with EC50 of 414.7 pM, activates adiponectin signalling via AdipoR1 but not AdipoR2.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CDRI-1709S is a highly potent, selective small molecule AdipoR1 (Adiponectin receptor 1) agonist with EC50 of 414.7 pM, activates adiponectin signalling via AdipoR1 but not AdipoR2.
CDRI-1709S promoted C2C12 myoblast differentiation into mature myotubes, accompanied by increased expression of MyoD and myogenin.
CDRI-1709S also reverses Dexamethasone‐mediated impairments in oxidative and glycolytic capacity.
CDRI-1709S activated hallmark adiponectin‐associated signalling events, including phosphorylation of AMPK, AKT and p38‐MAPK, in AdipoR1‐overexpressing HEK293T and AdipoR‐rich C2C12 myotubes.
CDRI-1709S protected myotubes against Dexamethasone, LPS + TNFα and PBS (nutrient deficiency)‐induced atrophy.
CDRI-1709S prevented dexamethasone‐induced skeletal muscle atrophy in SD rats.
Physicochemical Properties
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M.Wt
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262.24
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Formula
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C15H11NaO3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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sodium 6a,11a-dihydro-6H-benzofuro[3,2-c]chromen-3-olate
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References
1. Md Rameez Moin, et al. J Cachexia Sarcopenia Muscle. 2026 Aug;17(4):e70328.
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