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Chemical Structure : CEP-11981
Catalog No.: PC-70185Not For Human Use, Lab Use Only.
CEP-11981 (ESK981) is a potent, multi-targeted, orally active, pan-VEGFR, TIE-2 and FGFR1 inhibitor with IC50 of 3-100 nM.
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CEP-11981 (ESK981) is a potent, multi-targeted, orally active, pan-VEGFR, TIE-2 and FGFR1 inhibitor with IC50 of 3-100 nM; demonstrates a significant pre-clinical activity against human urothelial carcinoma (UC) xenografts.
Solid Tumors
Phase 1 Clinical
| M.Wt | 477.56 | |
| Formula | C28H27N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hudkins RL, et al. J Med Chem. 2012 Jan 26;55(2):903-13.
2. Jian W, et al. Anticancer Res. 2014 Jul;34(7):3377-82.
3. Levitt JM, et al. J Clin Oncol. 2013 Feb 20;31(6_suppl):293.
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