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Chemical Structure : CFI-401980
Catalog No.: PC-62727Not For Human Use, Lab Use Only.
CFI-401980 is a potent, selective, novel class TTK (Tyrosine Threonine Kinase, MPS1) inhibitor with Ki of 0.8 nM, HCT116 GI50 of 13 nM.
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CFI-401980 is a potent, selective, novel class TTK (Tyrosine Threonine Kinase, MPS1) inhibitor with Ki of 0.8 nM, HCT116 GI50 of 13 nM.
CFI-401980 shows exceptional kinase selectivity; demonstrate a strong anti-proliferative activity in a panel of human cancer cell lines (HCT116 GI50<15 nM) and good rodent pharmacokinetics (oral %F 97%).
| M.Wt | 498.587 | |
| Formula | C28H30N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Laufer R, et al. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3562-6.
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