Chemical Structure CFI-402257
CAS No.: 1610759-22-2
Catalog No.: PC-42354Not For Human Use, Lab Use Only.
A potent and selective Mps1/TTK kinase inhibitor with Ki of 0.1 nM and cellular Mps1 EC50 of 6.5 nM.
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A potent and selective Mps1/TTK kinase inhibitor with Ki of 0.1 nM and cellular Mps1 EC50 of 6.5 nM; exhibit effects consistent with Mps1 kinase inhibition, specifically SAC inactivation, leading to chromosome missegregation, aneuploidy, and ultimately cell death; well-tolerated in mouse models of human cancer and orally active.
DMSO: 10 mM (Need Warming and Ultrasonic)
1. Mason JM, et al. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3127-3132.
2. Liu Y, et al. ACS Med Chem Lett. 2016 May 6;7(7):671-5.