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Chemical Structure : CFMTI
CAS No.: 864864-17-5
Catalog No.: PC-42134Not For Human Use, Lab Use Only.
A potent, selective, allosteric and oral mGluR1 antaognist with IC50 of 2.6 and 2.3 nM for human and rat mGluR1, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $400 | In stock | |
| 10 mg | $560 | In stock | |
| 25 mg | $960 | In stock | |
| 50 mg | $1360 | In stock |
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A potent, selective, allosteric and oral mGluR1 antaognist with IC50 of 2.6 and 2.3 nM for human and rat mGluR1, respectively; displays >2,000-fold selectivity over mGluR5, and no actvity for other mGluR subtypes; reduces methamphetamine-induced hyperlocomotion and MK-801-induced social withdrawal without any cataleptogenic activities in mice.
| M.Wt | 349.3616 | |
| Formula | C19H16FN5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 6.2 mg/mL (Need warming) |
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| Chemical Name/SMILES |
1H-Isoindol-1-one, 2-cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro- |
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1. Satow A, et al. J Pharmacol Exp Ther. 2009 Jul;330(1):179-90.
2. Hikichi H, et al. Eur J Pharmacol. 2010 Aug 10;639(1-3):99-105.
3. Suzuki G, et al. Neuroscience. 2010 Jul 14;168(3):787-96.
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