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Chemical Structure : CGP-53353
CAS No.: 145915-60-2
Catalog No.: PC-62077Not For Human Use, Lab Use Only.
CGP-53353 (DAPH-7) is a selective inhibitor of PKCβII with IC50 of 0.41 uM, shows weak activity on PKCβI with IC50 of 3.8 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $238 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $588 | In stock | |
| 100 mg | Get quote |
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CGP-53353 (DAPH-7) is a selective inhibitor of PKCβII with IC50 of 0.41 uM, shows weak activity on PKCβI with IC50 of 3.8 uM.
CGP-53353 also inhibits prionogenic Sup35 fibrillization (IC50= 3.4 uM) and inhibits de novo Aβ42 assembly in vitro.
| M.Wt | 365.34 | |
| Formula | C20H13F2N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione |
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1. Kouroedov A, et al. Circulation. 2004 Jul 6;110(1):91-6.
2. Wang H, et al. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7159-64.
3. Chalfant CE, et al. Mol Endocrinol. 1996 Oct;10(10):1273-81.
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