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CGP049090

Chemical Structure : CGP049090

CAS No.: 35082-49-6

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CGP049090 (CGP 049090;Cercosporin)

Catalog No.: PC-61322Not For Human Use, Lab Use Only.

CGP049090 (Cercosporin) is a small-molecule that specifically inhibits the interaction of β-catenin/LEF1 transcriptional complex in colon carcinoma cell lines.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CGP049090 (Cercosporin) is a small-molecule that specifically inhibits the interaction of β-catenin/LEF1 transcriptional complex in colon carcinoma cell lines.
    CGP049090 efficiently kills CLL cells with LC50 of <1 uM, without significantly toxcity for normal B cells.
    CGP049090 is well tolerated and exhibits tumor inhibition in in vivo studies.

    Physicochemical Properties

    M.Wt 534.517
    Formula C29H26O10
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6,12-dihydroxy-8,9-bis((R)-2-hydroxypropyl)-7,10-dimethoxyperyleno[1,12-def][1,3]dioxepine-5,11-dione

    References

    1. Gandhirajan RK, et al. Neoplasia. 2010 Apr;12(4):326-35.

    2. Minke KS, et al. Eur J Haematol. 2009 Mar;82(3):165-75.

    3. Wei W, et al. Int J Cancer. 2010 May 15;126(10):2426-36.

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