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Chemical Structure : CGP57380
CAS No.: 522629-08-9
Catalog No.: PC-42633Not For Human Use, Lab Use Only.
CGP57380 is a cell-permeable, specific MNK1 inhibitor with IC50 of 2.2 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | Get quote |
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CGP57380 is a cell-permeable, specific MNK1 inhibitor with IC50 of 2.2 uM.
CGP57380 has no inhibitory activity on p38, JNK1, ERK1/2, etc.
CGP57380 inhibits phosphorylation of eIF4E in cellular assays with IC50 of 3 uM.
| M.Wt | 244.2278 | |
| Formula | C11H9FN6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 43 mg/mL |
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| Chemical Name/SMILES |
1H-Pyrazolo[3,4-d]pyrimidine-3,4-diamine, N3-(4-fluorophenyl)- |
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1. Knauf U, et al. Mol Cell Biol. 2001 Aug;21(16):5500-11.
2. Wen Q, et al. Oncotarget. 2016 May 10;7(19):27787-801.
3. Lim S, et al. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2298-307.
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