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CGS 21680

Chemical Structure CGS 21680

CAS No.: 120225-54-9

CGS 21680 (CGS-21680;CGS21680)

Catalog No.: PC-43385Not For Human Use, Lab Use Only.

CGS 21680 is a specific adenosine A2A subtype receptor agonist with Ki of 27 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CGS 21680 is a specific adenosine A2A subtype receptor agonist with Ki of 27 nM; significantly upregulates CD39 and CD73 expression, accelerates the ATP hydrolysis and adenosine generation; reduces the number of infiltrated granulocytes into the ischemic tissue in rat model of transient cerebral ischemia.

Hypertension

Discontinued

Physicochemical Properties

M.Wt 499.5197
Formula C23H29N7O6
CAS No. 120225-54-9
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

10 mM in DMSO

Chemical Name

Benzenepropanoic acid, 4-[2-[[6-amino-9-(N-ethyl-.beta.-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]-

Clinical Information

References

1. Nekooeian AA, et al. Br J Pharmacol. 1998 Apr;123(8):1666-72.

2. Phillis JW, et al. Brain Res. 1990 Feb 19;509(2):328-30.

3. Komaki S, et al. Neurosci Lett. 2012 Jul 26;522(1):21-4.

4. Melani A, et al. Brain Res. 2014 Mar 10;1551:59-72.

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