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CGS 21680 hydrochloride

Chemical Structure CGS 21680 hydrochloride

CAS No.: 124431-80-7

CGS 21680 hydrochloride (CGS-21680 Hydrochloride;CGS21680 Hydrochloride)

Catalog No.: PC-43386Not For Human Use, Lab Use Only.

CGS 21680 is a specific adenosine A2A subtype receptor agonist with Ki of 27 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CGS 21680 is a specific adenosine A2A subtype receptor agonist with Ki of 27 nM; significantly upregulates CD39 and CD73 expression, accelerates the ATP hydrolysis and adenosine generation; reduces the number of infiltrated granulocytes into the ischemic tissue in rat model of transient cerebral ischemia.

Hypertension

Discontinued

Physicochemical Properties

M.Wt 535.9806
Formula C23H30ClN7O6
CAS No. 124431-80-7
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

DMSO: ≥ 20 mg/mL

Chemical Name

3-(4-(2-((6-amino-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl)amino)ethyl)phenyl)propanoic acid hydrochloride

Clinical Information

References

1. Nekooeian AA, et al. Br J Pharmacol. 1998 Apr;123(8):1666-72.

2. Phillis JW, et al. Brain Res. 1990 Feb 19;509(2):328-30.

3. Komaki S, et al. Neurosci Lett. 2012 Jul 26;522(1):21-4.

4. Melani A, et al. Brain Res. 2014 Mar 10;1551:59-72.

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