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Chemical Structure : CGS 27023A
Catalog No.: PC-62946Not For Human Use, Lab Use Only.
CGS 27023A (MMI 270) is a potent, orally active MMP inhibitor with Ki of 8-43 nM for MMP1/2/3/9.
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CGS 27023A (MMI 270) is a potent, orally active MMP inhibitor with Ki of 8-43 nM for MMP1/2/3/9.
CGS 27023A shows growth-inhibitory effects in breast carcinoma, prostate, bladder, colon, lung adenocarcinoma, glioblastoma, and ovarian carcinoma cell line.
CGS 27023A protects the cartilage proteoglycan matrix in a partial meniscectomy model of osteoarthritis in rabbits.
| M.Wt | 429.916 | |
| Formula | C18H24ClN3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Qian LW, et al. Clin Cancer Res. 2002 Apr;8(4):1223-7.
2. Levitt NC, et al. Clin Cancer Res. 2001 Jul;7(7):1912-22.
3. Eskens FA, et al. Clin Cancer Res. 2000 Feb;6(2):431-3.
4. Rossello A, et al. Bioorg Med Chem. 2004 May 1;12(9):2441-50.
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