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Chemical Structure : CHDI-390576
Catalog No.: PC-35827Not For Human Use, Lab Use Only.
CHDI-390576 (CHDI390576) is a potent, cell permeable and CNS penetrant class IIa HDAC inhibitor with IC50 of 54/60/31/50 nM for HDAC4/5/7/9, respectively.
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CHDI-390576 (CHDI390576) is a potent, cell permeable and CNS penetrant class IIa HDAC inhibitor with IC50 of 54/60/31/50 nM for HDAC4/5/7/9, respectively,
CHDI-390576 displays >500-fold selectivity over class I HDAC/1/2/3 and 150-fold selectivity over HDAC8 and the class IIb HDAC6.
CHDI-390576 was well-tolerated and showed no significant effect on passive observations, responses to manipulations, body weight, or body temperature in PK studies.
| M.Wt | 391.326 | |
| Formula | C19H13F4N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Luckhurst CA, et al. Bioorg Med Chem Lett. 2018 Nov 13. pii: S0960-894X(18)30858-8. doi: 10.1016/j.bmcl.2018.11.009.
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