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Chemical Structure : CHF6001
CAS No.: 1239278-59-1
Catalog No.: PC-60725Not For Human Use, Lab Use Only.
Tanimilast (CHF6001) is a novel, highly potent and selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 0.026 nM.
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|---|---|---|---|
| 5 mg | $458 | In stock | |
| 10 mg | $758 | In stock | |
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| 100 mg | Get quote |
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Tanimilast (CHF6001) is a novel, highly potent and selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 0.026 nM.
CHF6001 inhibits PDE4 isoforms A-D with equal potency, 7- and 923-fold more potent than roflumilast and cilomilast, and displays >20,000-fold selectivity versus PDE4 compared with a panel of PDEs.
CHF6001 effectively inhibits (subnanomolar IC50 values) the release of TNF-α from human PBMCs, THP-1, and rodent macrophages.
CHF6001 inhibitsLPS-induced pulmonary neutrophilia (ED50=0.205 uM/kg) and leukocyte infiltration (ED50=0.188 uM/kg) in rats.
| M.Wt | 687.533 | |
| Formula | C30H30Cl2F2N2O8S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoyloxy)ethyl)pyridine 1-oxide |
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1. Armani E, et al. J Med Chem. 2014 Feb 13;57(3):793-816.
2. Villetti G, et al .J Pharmacol Exp Ther. 2015 Mar;352(3):568-78.
3. Moretto N, et al. J Pharmacol Exp Ther. 2015 Mar;352(3):559-67.
4. Edwards MR, et al. Pharmacol Res Perspect. 2016 Jan 15;4(1):e00202.
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