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Chemical Structure : CHF6297
Catalog No.: PC-22072Not For Human Use, Lab Use Only.
CHF6297 (CHF-6297) is a potent and selective p38α/β MAPK inhibitor with IC50 of 0.14/0.2 nM, >1,000-fold selectivity against p38γ and p38δ.
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CHF6297 (CHF-6297) is a potent and selective p38α/β MAPK inhibitor with IC50 of 0.14/0.2 nM, >1,000-fold selectivity against p38γ and p38δ.
CHF6297 inhibits IL-8 release evoked by CSE in HBSMCs with IC50 of 0.79 nM.
CHF6297 dose-dependently counteractes the IL-1β (0.3 mg/kg)-induced neutrophil influx (ED50 = 0.22 mg/kg) and increase in IL-6 levels (ED50 = 0.82 mg/kg) in the BALF of rats.
CHF6297 (0.1 mg/kg, i.n.) significantly decreases airway neutrophilia in murine house dust mite (HDM) model of asthma exacerbated by influenza virus A (IAV) (H3N3).
CHF6297 effectively counteracteds lung inflammation in experimental models.
| M.Wt | 446.51 | |
| Formula | C24H26N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cataldo Martucci, et al. Front Pharmacol. 2024 Mar 14:15:1343941.
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