 
                Chemical Structure : CHIR-090
CAS No.: 728865-23-4
Catalog No.: PC-23202Not For Human Use, Lab Use Only.
CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase, binds to E. coli LpxC with Ki of 4.0 nM, displays good antimicrobial activity against several Gram-negative bacteria.
| Packing | Price | Stock | Quantity | 
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
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CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase, binds to E. coli LpxC with Ki of 4.0 nM, displays good antimicrobial activity against several Gram-negative bacteria.
| M.Wt | 437.50 | |
| Formula | C24H27N3O5 | |
| Appearance | Solid | |
| Storage | 
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| Solubility | 10 mM in DMSO | |
| Chemical Name/SMILES | N-((2S,3R)-3-Hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl)-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamide | |
1. McClerren AL, et al. Biochemistry. 2005 Dec 20;44(50):16574-83.
2. Barb AW, et al. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18433-8.
3. Bodewits K, et al. Antimicrob Agents Chemother. 2010 Aug;54(8):3531-3.

 
                 
                 
                 
                 
                 
                 
                 
                 
            
            
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