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CJ-13610

Chemical Structure : CJ-13610

CAS No.: 179420-17-8

CJ-13610 (CJ13610)

Catalog No.: PC-62454Not For Human Use, Lab Use Only.

CJ-13610 is a potent 5-Lipoxygenase (5-LO) inhibitor that suppresses 5-LO product formation with IC50 of 70 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CJ-13610 is a potent 5-Lipoxygenase (5-LO) inhibitor that suppresses 5-LO product formation with IC50 of 70 nM; demonstrates antihyperalgesic activity in inflammatory pain models including the acute carrageenan model and the chronic inflammatory model.

Asthma

Phase 2 Discontinued

Physicochemical Properties

M.Wt 393.505
Formula C22H23N3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

tetrahydro-4-[3-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]thio]phenyl]-2H-pyran-4-carboxamide

References

1. Fischer L, et al. Br J Pharmacol. 2004 Jul;142(5):861-8.

2. Cortes-Burgos LA, et al. Eur J Pharmacol. 2009 Sep 1;617(1-3):59-67.

3. von Knethen A, et al. Cell Signal. 2013 Dec;25(12):2762-8.

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