Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Wnt/Notch/Hedgehog-Casein Kinase-CKR-49-17
CKR-49-17

Chemical Structure : CKR-49-17

CAS No.:

Add to Favorites

CKR-49-17

Catalog No.: PC-21547Not For Human Use, Lab Use Only.

CKR-49-17 is a potent, allosteric small molecule activator of CK1γ2 with Kd value of 180 nM in MST assays, inhibits CK1γ2 autophosphorylation.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
200 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CKR-49-17 is a potent, allosteric small molecule activator of CK1γ2 with Kd value of 180 nM in MST assays, inhibits CK1γ2 autophosphorylation.
    CKR-49-17 increases phosphorylation of Presenilin 1 (PS1)-pS367 in vitro with IC50 of 60 uM.
    CKR-49-17 shows binding affinity for CK1γ2 D128A mutant with SPR Kd of 750 nM.
    CKR-49-17 decreased C99 levels with IC50 of 15 uM in N2A cells stably overexpressing APP-695, decreased the levels of Aβ40 and Aβ42.

    Physicochemical Properties

    M.Wt 391.49
    Formula C21H21N5OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(6-cyanobenzo[d]thiazol-2-yl)-4-((piperidin-4-ylamino)methyl)benzamide

    References

    1. Bustos VH, et al. ACS Chem Biol. 2023 Dec 11. doi: 10.1021/acschembio.3c00425.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: