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CLK inhibitor T3

Chemical Structure : CLK inhibitor T3

CAS No.: 2109805-56-1

CLK inhibitor T3 (T3-CLK, CLK-T3)

Catalog No.: PC-61021Not For Human Use, Lab Use Only.

CLK inhibitor T3 (T3) is a highly potent, selective, and cell-based stable CDC-like kinase (CLK) inhibitor with 0.67, 15 and 110 nM for CLK1,2 and 3, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CLK inhibitor T3 (T3) is a highly potent, selective, and cell-based stable CDC-like kinase (CLK) inhibitor with 0.67, 15 and 110 nM for CLK1,2 and 3, respectively.
CLK inhibitor T3 (T3) displays 200-300-fold selectivity over other dual specificity kinases such as DYRK1A and DYRK1B.
CLK inhibitor T3 (T3) induces dose-dependent reduction in exon recognition and exhibits an overlapping, but greater effect on transcriptome splicing compared to KH-CB19.

Physicochemical Properties

M.Wt 482.588
Formula C28H30N6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(2-methyl-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl)-N-(6-(pyridin-4-yl)imidazo[1,2-a]pyridin-2-yl)benzamide

References

1. Funnell T, et al. Nat Commun. 2017 Feb 23;8(1):7.

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