Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Aldehyde Dehydrogenase (ALDH)-CLM296
CLM296

Chemical Structure : CLM296

CAS No.: 3067837-25-3

Add to Favorites

CLM296 (CLM-296)

Catalog No.: PC-26285Not For Human Use, Lab Use Only.

CLM296 (CLM-296) is a highly potent, selective inhibitor of Aldehyde dehydrogenase 1A3 (ALDH1A3) with IC50 of 2 nM for inhibition of ALDH1A3 in TNBC cells.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CLM296 (CLM-296) is a highly potent, selective inhibitor of Aldehyde dehydrogenase 1A3 (ALDH1A3) with IC50 of 2 nM for inhibition of ALDH1A3 in TNBC cells.
CLM296 inhibits ALDH1A3-mediated Aldefluor fluorescence and is specific for ALDH1A3.
CLM296 (100 nM) specifically blocks ALDH1A3-mediated gene expression changes in TNBC cells.
CLM296 (0.4 and 4 mg/kg, i.p.) in specifically impedes ALDH1A3-mediated tumor growth and metastasis in MDA-MB-231 ALDH1A3 OE tumor-bearing mice.

Physicochemical Properties

M.Wt 430.51
Formula C29H22N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,1'-((2-phenylimidazo[1,2-a]pyridine-6,8-diyl)bis(4,1-phenylene))bis(ethan-1-one)

References

1. MacLean MR, et al. iScience. 2026 Jan 31;29(3):114863.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: