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Chemical Structure : CM-1758
Catalog No.: PC-21607Not For Human Use, Lab Use Only.
CM-1758 is a novel histone deacetylase (HDAC) inhibitor with IC50 of 5 nM and 126 nM for HDAC1 and HDAC6, respectively.
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CM-1758 is a novel histone deacetylase (HDAC) inhibitor with IC50 of 5 nM and 126 nM for HDAC1 and HDAC6, respectively.
CM-1758 displays cytotoxic/cytostatic effects in bladder cancer cells with ow micromolar range (IC50=0.33-4.8 uM).
CM-1758 induces profound changes in the transcriptomic profile of BC cells, affecting pathways related to tumor cell aggressiveness and epigenetic machinery.
CM-1758 treatment affects histone acetylation, but also other epigenetic mechanisms, such as DNA methylation indirectly.
Anti-PD-L1 alone or in combination with CM-1758 reprogramed macrophage differentiation towards a M1-like polarization state and increased of pro-inflammatory cytokines systemically, yielding potential further antitumor effects.
| M.Wt | 532.60 | |
| Formula | C28H32N6O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rabal O, et al. J Med Chem. 2021;64:3392–426.
2. Nunes SP, et al. Cell Death Discov. 2024 Jan 4;10(1):1.
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