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Chemical Structure : CM-304
Catalog No.: PC-21110Not For Human Use, Lab Use Only.
CM-304 is a potent, selective sigma-1 receptor (S1R) antagonist with Ki of 3.41 nM, 100-fold selective over S2R.
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CM-304 is a potent, selective sigma-1 receptor (S1R) antagonist with Ki of 3.41 nM, 100-fold selective over S2R.
CM-304 also shows >10,000-fold selectivity over 59 other targets, including opioid and 5-HT receptors.
CM-304 demonstrated anti-allodynic effects in the CCI assay.
CM-304demonstrated dose-dependent antinociception following i.p. administration in the mouse acetic-acid writhing assay.
| M.Wt | 336.47 | |
| Formula | C18H25FN2OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cirino TJ, et al. Front Pharmacol. 2019 Jun 14;10:678.
2. James M. L, et al. J. Med. Chem. 55 (19), 8272–8282.
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