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Chemical Structure : CM-352
Catalog No.: PC-20536Not For Human Use, Lab Use Only.
CM-352 (CM352) is an antihemorrhagic agent that potently inhibit MMP-10 and MMP-3 (IC50 of 12 and 15 nM, respectively), inhibits fibrinolysis in human whole blood functional assays with EC50 of 0.7 nM.
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CM-352 (CM352) is an antihemorrhagic agent that potently inhibit MMP-10 and MMP-3 (IC50 of 12 and 15 nM, respectively), inhibits fibrinolysis in human whole blood functional assays with EC50 of 0.7 nM.
CM-352 displays no significant acitvity against a panel of 84 different protein targets bearing metal-binding sites (e.g., cathepsins, caspases, HDACs, etc.) at 10 uM.
CM-352 behaved as a pan-MMP inhibitor, displaying greater than 93% inhibition for eight different MMPs (MMP-1, -2, -8, -9, -12, -13, -14, and -20) and greater than 73% for MMP-7 at 10 uM.
CM-352 (200 nM) delayed fibrinolysis front velocity induced by tPA (76% reduction) and exhibited higher antifibrinolytic activity than tranexamic acid (TXA) in whole blood.
CM-352 reduced blood loss during liver hepatectomy in vivo.
| M.Wt | 487.57 | |
| Formula | C24H29N3O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Orbe J, et al. J Med Chem. 2015 Apr 9;58(7):2941-57.
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