CM-675 (CM675) is a potent, dual PDE5 and classI-HDAC inhibitor with IC50 of 114/673 nM for PDE5A/HDAC1, respectively.
CM-675 displays >10-fold selectivity over HDAC6.
CM-675 induces significant cellular responses (AcH3K9 and pCREB) at low concentrations (26-100 nM) with little cytotoxicity.
CM-675 shows an adequate ADME-Tox profile and in vivo target engagement (histone acetylation and cAMP/cGMP response element-binding (CREB) phosphorylation) in the central nervous system (CNS).
