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Chemical Structure : CM-675
Catalog No.: PC-35926Not For Human Use, Lab Use Only.
CM-675 (CM675) is a potent, dual PDE5 and classI-HDAC inhibitor with IC50 of 114/673 nM for PDE5A/HDAC1, respectively.
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CM-675 (CM675) is a potent, dual PDE5 and classI-HDAC inhibitor with IC50 of 114/673 nM for PDE5A/HDAC1, respectively.
CM-675 displays >10-fold selectivity over HDAC6.
CM-675 induces significant cellular responses (AcH3K9 and pCREB) at low concentrations (26-100 nM) with little cytotoxicity.
CM-675 shows an adequate ADME-Tox profile and in vivo target engagement (histone acetylation and cAMP/cGMP response element-binding (CREB) phosphorylation) in the central nervous system (CNS).
| M.Wt | 536.636 | |
| Formula | C31H32N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rabal O, et al. ACS Chem Neurosci. 2018 Dec 10. doi: 10.1021/acschemneuro.8b00648.
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