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Chemical Structure : CM572
Catalog No.: PC-60747Not For Human Use, Lab Use Only.
CM572 is a potent, selective, irreversible sigma-2 receptor partial agonist with Ki of 14.6 nM, >700-fold selectivity over sigma-1 receptors.
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CM572 is a potent, selective, irreversible sigma-2 receptor partial agonist with Ki of 14.6 nM, >700-fold selectivity over sigma-1 receptors.
CM572 induces dose-dependent cell death in SK-N-SH cells with EC50 of 7.6 uM.
CM572 also demonstrates selective cytotoxic activity against PANC-1 pancreatic and MCF-7 breast cancer cell lines, with no significant effect on normal cells.
| M.Wt | 426.51 | |
| Formula | C22H23FN4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nicholson H, et al. J Pharmacol Exp Ther. 2015 Aug;354(2):203-12.
2. Nicholson H, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):232-43.
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