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Chemical Structure : CM764
Catalog No.: PC-60750Not For Human Use, Lab Use Only.
CM764 is a potent, selective sigma-2 receptor agonist with Ki of 3.5 nM, 25-fold selectivity over sigma-1 receptors (Ki=86.6 nM).
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CM764 is a potent, selective sigma-2 receptor agonist with Ki of 3.5 nM, 25-fold selectivity over sigma-1 receptors (Ki=86.6 nM).
CM764 increases reduction of MTT in human SK-N-SH neuroblastoma, produces an immediate, robust, and transient increase in cytosolic calcium, consistent with sigma-2 receptor activation.
CM764 increases total NAD(+)/NADH level, the ATP level, HIF1α and VEGF levelsin SK-N-SH cells.
| M.Wt | 426.492 | |
| Formula | C23H27FN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nicholson H, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):232-43.
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