Chemical Structure : CMC2.24
CAS No.: 1255639-43-0
Catalog No.: PC-63506Not For Human Use, Lab Use Only.
CMC2.24 (TRB-N0224) is a novel tricarbonylmethane agent that inhibits the Ras-RAF-MEK-ERK pathway, inhibits Ras activation in pancreatic cancer both in vitro and in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $278 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | $758 | In stock | |
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CMC2.24 (TRB-N0224) is a novel tricarbonylmethane agent that inhibits the Ras-RAF-MEK-ERK pathway, inhibits Ras activation in pancreatic cancer both in vitro and in vivo.
CMC2.24 inhibits Ras-GTP in MIA PaCa-2 cells and in pancreatic acinar explants isolated from KRas mutant mice.
CMC2.24 inhibits ERK1/2 activation in pancreatic cancer cells and xenografts, inhibits pancreatic cancer growth, inhibits the growth of pancreatic cancer xenografts.
| M.Wt | 427.456 | |
| Formula | C26H21NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2E,4E)-3-hydroxy-5-(4-hydroxyphenyl)-2-((E)-3-(4-hydroxyphenyl)acryloyl)-N-phenylpenta-2,4-dienamide |
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1. Mallangada NA, et al. Mol Carcinog. 2018 Apr 23. doi: 10.1002/mc.22830.

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