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Chemical Structure : CMLD010509
Catalog No.: PC-60542Not For Human Use, Lab Use Only.
A rocaglate (flavagline) derivative that acts a highly specific inhibitor of the oncogenic translation program supporting MM, including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1.
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A rocaglate (flavagline) derivative that acts a highly specific inhibitor of the oncogenic translation program supporting MM, including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1; induces apoptosis and inhibits the heat shock response in MM cells (IC50=10 nM), a potent and selective translation inhibitor through an eIF4E phosphorylation-independent mechanism and is highly effective in vivo in several mouse models.
| M.Wt | 556.409 | |
| Formula | C27H26BrNO7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Manier S, et al. Sci Transl Med. 2017 May 10;9(389). pii: eaal2668.
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