Catalog No.: PC-60542Not For Human Use, Lab Use Only.
CMLD010509 (SDS-1-021) is a rocaglate (flavagline) derivative that acts a highly specific inhibitor of the oncogenic translation program supporting MM, including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1.
CMLD010509 (SDS-1-021) is a rocaglate (flavagline) derivative that acts a highly specific inhibitor of the oncogenic translation program supporting MM, including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1.
CMLD010509 induces apoptosis and inhibits the heat shock response in MM cells (IC50=10 nM).
CMLD010509 is a potent and selective translation inhibitor through an eIF4E phosphorylation-independent mechanism and is highly effective in vivo in several mouse models.
