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CMS121

Chemical Structure : CMS121

CAS No.: 1353224-53-9

CMS121 (CMS-121, CMS 121)

Catalog No.: PC-21269Not For Human Use, Lab Use Only.

CMS121 is a small molecule fatty acid synthase (FASN) inhibitor, reduces lipid peroxidation and neuroinflammation both in vitro and in vivo.

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Biological Activity

CMS121 is a small molecule fatty acid synthase (FASN) inhibitor, reduces lipid peroxidation and neuroinflammation both in vitro and in vivo.
CMS121 is able to rescue cells from oxytotic/ferroptotic cell death.
CMS121 decreases lipid peroxidation and has anti-inflammatory properties, modulates lipid metabolism.
CMS121 alleviates cognitive loss, modulates lipid metabolism and reduces inflammation and lipid peroxidation in the brains of transgenic AD mice.

Physicochemical Properties

M.Wt 321.38
Formula C20H19NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol

References

1. Gamze Ates, et al. Redox Biol. 2020 Sep:36:101648.

2. Prior M., et al. ACS Chem. Neurosci. 2014;5:503–513.

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