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Chemical Structure : CNB-001
CAS No.: 1019110-87-2
Catalog No.: PC-20458Not For Human Use, Lab Use Only.
CNB-001 is a pyrazole derivative of curcumin with neuroprotective properties, inhibits extracellular Aβ toxicity in hippocampal neurons with EC50 of 400 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $248 | In stock | |
| 100 mg | $548 | In stock | |
| 200 mg | $728 | In stock | |
| 1 g | Get quote |
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CNB-001 is a pyrazole derivative of curcumin with neuroprotective properties, inhibits extracellular Aβ toxicity in hippocampal neurons with EC50 of 400 nM.
CNB-001 inhibits amyloid-induced cell death in the MC65 system with EC50 of 300 nM, CNB-001 also inhibits the accumulation of Aβ and APP C-terminal aggregates in MC65 cells.
CNB001 significantly suppressed IL-6, TNF-alpha, and GM-CSF production by NHBE cells.
NB-001 (1-10 µM) suppressed the lipopolysaccharide (LPS)-induced nitric oxide (NO) production and expression of inducible NO synthase (iNOS) in primary cultured rat microglia.
CNB-001 significantly suppressed the LPS-induced phosphorylation of p38 MAPK, but not ERK and JNK.
| M.Wt | 440.50 | |
| Formula | C27H24N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4,4'-((1E,1'E)-(1-phenyl-1H-pyrazole-3,5-diyl)bis(ethene-2,1-diyl))bis(2-methoxyphenol) |
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1. Liu Y, et al. J Neurochem. 2008 May;105(4):1336-45.
2. Lapchak PA, et al. J Neurochem. 2011 Jan;116(1):122-31.
3. Panzhinskiy E, et al. J Pharmacol Exp Ther. 2014 May;349(2):248-57.
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