Chemical Structure : CNiBuC
CAS No.:
2848677-53-0
CNiBuC
(5′-isobutyril prodrug of 1′-cyanocytidine)
Catalog No.: PC-25844Not For Human Use, Lab Use Only.
CNiBuC is the 5′-isobutyril ester prodrug of 1'-cyanocytidine and a reversible, competitive inhibitor of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), shows anti-SARS-CoV-2 activity with EC50 of 3.6 uM in Vero cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CNiBuC is the 5′-isobutyril ester prodrug of 1'-cyanocytidine and a reversible, competitive inhibitor of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), shows anti-SARS-CoV-2 activity with EC50 of 3.6 uM in Vero cells.
CNiBuC had micro-to-nanomolar anti–SARS-CoV-2 activity in Vero, Calu-3, and Caco-2 cell lines.
CNiBuC (50 and 100 mg/kg, i.p., twice daily)reduces infectious virus titers against DELTA SARS-CoV-2 variant in Syrian hamsters.
Physicochemical Properties
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M.Wt
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338.32
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Formula
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C14H18N4O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl isobutyrate
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References
1. Amblard F, et al. Sci Adv. 2025 Oct 3;11(40):eadz5913.
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