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Chemical Structure : COE2-2hexyl
Catalog No.: PC-49758Not For Human Use, Lab Use Only.
COE2-2hexyl is a broad-spectrum antibacterial conjugated oligoelectrolyte (COE), does not evoke bacterial resistance, inhibits methicillin-resistant S. aureus (MRSA, MT3302) with MIC of 1 ug/mL.
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COE2-2hexyl is a broad-spectrum antibacterial conjugated oligoelectrolyte (COE), does not evoke bacterial resistance, inhibits methicillin-resistant S. aureus (MRSA, MT3302) with MIC of 1 ug/mL.
COE2-2hexyl effectively killed both S. Typhimurium 14028 (MIC=2 ug/mL) and CA-MRSA USA300 (MIC=1 ug/mL), with bactericidal activity kinetics similar to that of ciprofloxacin (CIP) treatment.
COE2-2hexyl effectively treated mice infected with multidrug-resistant (MDR) bacteria and was not prone to bacterial resistance.
COE2-2hexyl exhibited broad-spectrum antibacterial activity, showed low cytotoxicity in cultured mammalian cells.
| M.Wt | 1601.47 | |
| Formula | C70H132I4N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Douglas M Heithoff, et al. EBioMedicine. 2023 Feb 14;104461.
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