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Chemical Structure : CP-481715
Catalog No.: PC-61967Not For Human Use, Lab Use Only.
CP-481715 is a potent and selective CCR1 antagonist with Ki of 9.2 nM and IC50 of 74 nM, lacks intrinsic agonist activity.
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CP-481715 is a potent and selective CCR1 antagonist with Ki of 9.2 nM and IC50 of 74 nM, lacks intrinsic agonist activity.
CP-481715 displays >100-fold selectiveity over a panel of GPCRs including related chemokine receptors.
CP-481715 fully blocks the ability of CCL3 and CCL5 to stimulate receptor signaling (calcium mobilization, IC50=71 nM), monocyte chemotaxis, IC50= 55 nM, and MMP 9 release, IC50= 54 nM).
CP-481715 inhibits cell infiltration and inflammatory responses in human CCR1 transgenic mice.
| M.Wt | 482.556 | |
| Formula | C26H31FN4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gladue RP, et al. J Biol Chem. 2003 Oct 17;278(42):40473-80.
2. Gladue RP, et al. J Immunol. 2006 Mar 1;176(5):3141-8.
3. Gilchrist A, et al. Br J Pharmacol. 2014 Nov;171(22):5127-38.
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