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Chemical Structure : CP-673451
CAS No.: 343787-29-1
Catalog No.: PC-42865Not For Human Use, Lab Use Only.
CP-673451 is a potent, selective, orally acitve PDGFR inhibitor with IC50 of 1 and 10 nM for PDGFR-α and PDGFR-β, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
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CP-673451 is a potent, selective, orally acitve PDGFR inhibitor with IC50 of 1 and 10 nM for PDGFR-α and PDGFR-β, respectively.
CP-673451 inhibits PDGFR-β autophosphorylation with IC50 of 1 nM in cell-based assyas, displays >450-fold selectivity over other angiogenic receptors, including VEGFR-1, VEGFR-2, TIE-2, and FGFR-2.
CP-673451 inhibits PDGFR phosphorylation in tumor xenografts and inhibits multiple types tumor growth in vivo.
CP-673451 also robustly inhibits centrosome clusterin, induces mitotic spindle multipolarity by activation of the actin-severing protein cofilin in cancer cells.
| M.Wt | 417.5035 | |
| Formula | C24H27N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-Piperidinamine, 1-[2-[5-(2-methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]- |
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1. Roberts WG, et al. Cancer Res. 2005 Feb 1;65(3):957-66.
2. Ehnman M, et al. Cancer Res. 2013 Apr 1;73(7):2139-49.
3. Chintalgattu V, et al. Sci Transl Med. 2013 May 29;5(187):187ra69.
4. Konotop G, et al. Cancer Res. 2016 Nov 15;76(22):6690-6700.
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