Chemical Structure : CP612
CAS No.:
CP612
(CIDD-0150612)
Catalog No.: PC-24452Not For Human Use, Lab Use Only.
CP612 (CIDD-0150612) is a potent, specific inhibitor of protein kinase C epsilon (PKC epsilon, PKCε) with IC50 of 1.1 nM, 40-fold more selective against PKCε over ROCK1.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CP612 (CIDD-0150612) is a potent, specific inhibitor of protein kinase C epsilon (PKC epsilon, PKCε) with IC50 of 1.1 nM, 40-fold more selective against PKCε over ROCK1.
CP612 did not inhibit atypical PKCζ, weakly inhibited conventional PKCβII and PKCγ, and within the nPKC subfamily, and a clean selectivity against 468 kinases using the scanMax assay panel from Eurofins-DiscoverX (468 kinases).
CP612 inhibits PKCε by competing with ATP.
CP612 could enter the brain and is cleared from brain at a much slower rate than from plasma.
CP612 inhibits PKCε-dependent mechanical hyperalgesia, does not alter morphine self-administration.
CP612 prevents and reverses hyperalgesia induced by morphine withdrawal.
CP612 shows beneficial effects on insulin action in hepatocytes and on fat mass and glucose homeostasis in mice.
Physicochemical Properties
|
M.Wt
|
462.98
|
|
Formula
|
C26H27ClN4O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(S)-4-(1-amino-2-(1-(4-chlorophenyl)cyclopentane-1-carboxamido)ethyl)-N-(pyridin-4-yl)benzamide
|
References
1. Gregory-Flores A, et al. bioRxiv : the preprint server for biology, 2023 (2023), Article 543325
2. Agoncillo ML, et al. Eur J Pharmacol. 2025 Mar 5:177465.
Contact Us
sales@probechem.com
