Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : CPL500036
Catalog No.: PC-72597Not For Human Use, Lab Use Only.
CPL500036 (CPL-500036) is a highly potent, selective and orally bioavailable PDE10A inhibitor with IC50 of 35 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
CPL500036 (CPL-500036) is a highly potent, selective and orally bioavailable PDE10A inhibitor with IC50 of 35 nM.
CPL500036 is highly selective for PDE10A over other PDEs and common off-targets.
CPL500036 effectively penetrates the brain where increases cAMP/cGMP levels and phosphorylates effector proteins like AMPA subunits.
CPL500036 reduced sensorimotor deficits in 6-OHDA-lesioned rats.
Acute and chronic CPL500036 did not reduce effects of L-DOPA in sensorimotor tests.
Chronic CPL500036 treatment did not decrease L-DOPA-induced contralateral rotation.
| M.Wt | 341.378 | |
| Formula | C19H15N7 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Tomasz Lenda, et al. Eur J Pharmacol. 2021 Nov 5;910:174460.
2. Moszczyński-Pętkowski R, et al. Eur J Med Chem. 2018 Jul 15;155:96-116.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
