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Chemical Structure : CPYPP
CAS No.: 310460-39-0
Catalog No.: PC-62450Not For Human Use, Lab Use Only.
CPYPP is a small-molecule inhibitor of the Rac activator DOCK2 with IC50 of 22.8 uM (DOCK2DHR-2-mediated Rac GEF activity), inhibits DOCK2-Rac1 interaction.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
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CPYPP is a small-molecule inhibitor of the Rac activator DOCK2 with IC50 of 22.8 uM (DOCK2DHR-2-mediated Rac GEF activity), inhibits DOCK2-Rac1 interaction.
CPYPP binds to DOCK2 DHR-2 domain in a reversible manner and inhibited its catalytic activity in vitro.
CPYPP blocks both chemokine receptor- and antigen receptor-mediated Rac activation in lymphocytes, resulting in marked reduction of chemotactic response and T cell activation.
| M.Wt | 324.764 | |
| Formula | C18H13ClN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione |
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1. Nishikimi A, et al. Chem Biol. 2012 Apr 20;19(4):488-97.
2. Watanabe M, et al. J Immunol. 2014 Dec 1;193(11):5660-7.
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